High school senior Peter Parker (Tobey Maguire) lives in Forest Hills, a quiet neighborhood in the New York City borough of Queens, with his Uncle Ben (Cliff Robertson) and Aunt May (Rosemary Harris). He secretly loves Mary Jane Watson (Kirsten Dunst), a warm-hearted girl next door, but he is too shy to approach her. His friend Harry Osborn (James Franco) is the son of Dr. Norman Osborn (Willem Dafoe), president of the Oscorp manufacturing corporation, which is working to win a contract to supply weapons to the United States Army. On a field trip to a genetics laboratory, Peter is bitten by a genetically engineered spider. He passes out in his bedroom at home, and the next day his vision is perfect, he has become more muscular with superhuman strength, his wrists emit web strings, and his reflexes are super-quick. At school, he saves Mary Jane from a split-second fall and easily defeats her bullying boyfriend in a fistfight. Realizing that the spider's bite has given him spiderlike powers, he trains himself to scale walls, jump between rooftops, and swing through the city.